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A wave of injuries is reshaping NFL rosters, with star quarterbacks and key defenders facing extended absences. Lamar Jackson’s season-ending thumb surgery leaves the Ravens with an uncertain QB situation, while the Cardinals pivot to Gardner Minshew amid their own signal-caller instability. Defensive standouts like Derwin James Jr. are also being sidelined, compounding teams’ challenges. The league’s disciplinary actions, including fines for unnecessary roughness and unsportsmanlike conduct, highlight ongoing concerns about player safety and on-field behavior. These developments may force teams to rely on unproven backups and adjust strategies mid-season.